Livedoid vasculitis - Livedoid Vaskulit
Livedoid Vaskulit (Livedoid vasculitis) asosan yosh va o'rta yoshdagi ayollarda kuzatiladigan surunkali teri kasalligi. Uning xususiyatlarini tavsiflash uchun ishlatiladigan qisqartmalardan biri "pastki ekstremitalarning retikulyar naqshli og'riqli purpurik yaralari" (PURPLE). Bu bir qator kasalliklar, jumladan, surunkali venoz gipertenziya va varikozlar bilan bog'liq.
☆ Germaniyaning 2022 yilgi Stiftung Warentest natijalariga ko'ra, iste'molchilarning ModelDermdan qoniqish darajasi pullik teletibbiyot maslahatlariga qaraganda bir oz pastroq bo'lgan.
Bu og'riq bilan birga bo'lishi mumkin.
References
Livedoid vasculopathy - kamdan-kam uchraydigan teri kasalligi bo'lib, pastki oyoqlarda doimiy ravishda og'riqli yaralar paydo bo'lishi bilan tavsiflanadi.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy kamdan-kam uchraydigan teri kasalligi bo'lib, pastki oyoqlarda takroriy yaralar paydo bo'lib, atrofiya blansh deb nomlanuvchi rangpar chandiqlar qoldiradi. Aniq sabab hali noma'lum bo'lsa-da, qon ivishining kuchayishi (hypercoagulability) asosiy omil bo'lib, yallig'lanish ikkinchi darajali rol o'ynaydi. Qon ivishiga yordam beruvchi omillarga quyidagilar kiradi - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. Biopsiyada bu holat tomirlar ichidagi qon pıhtılarını, tomir devorlarining qalinlashishini va chandiqlarni ko'rsatadi. Davolash trombotsitlarga qarshi dorilar, qonni suyultiruvchi vositalar va fibrinolitik terapiya kabi dorilar yordamida qon pıhtılarının oldini olishga qaratilgan ko'p qirrali yondashuvni o'z ichiga oladi. Ushbu teri holati uchun turli xil dorilarni qo'llash mumkin - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy kamdan-kam uchraydigan holat bo'lib, unda ikkala oyoqda jarohatlar paydo bo'ladi. Kichkina qon tomirlarida qon pıhtılarının paydo bo'lishi qon ivishining kuchayishi va qon ivishining kamayishi, tomir qoplamasining shikastlanishi bilan bog'liq deb taxmin qilinadi. Ayniqsa, 15 yoshdan 50 yoshgacha bo'lgan ayollarda bu ko'proq uchraydi. Chekishni tashlash, yaralarni parvarish qilish, qonni suyultiruvchi va trombotsitlarga qarshi dorilar kabi dorilarni qo'llash samarali bo'ldi.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
